Author

Jack Devlin

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Biophysics· 1

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

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Isaac MacwaniD· 1 shared Jenna Madigan· 1 shared

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1 shared paperBiophysics

Isaac MacwanORCID

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1 paper

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BiophysicsbioRxivPreprintJan 31, 2024

Onset of Mismatch Repair by the Human Mismatch Repair Protein, MutSbeta for a Biosensing Device

Jack Devlin, Jenna Madigan, Isaac Macwan

The paper uses molecular dynamics simulations to study how MutSbeta interacts with mismatched DNA, showing its stabilization and scanning initiation after ~75ns, and validates these findings for a biosensing application.

DOI 10.1101/2024.01.31.578329

humanmechanistic / dynamical model

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