Author

Jacob G. Jansen

Leiden University Medical Center

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Approach:experimental assay· 1

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Anastasia Tsaalbi-Shtylik· 1 shared Daniel C. de Groot· 1 shared Heinz JacobsiD· 1 shared Karoly Szuhai· 1 shared Niels de WindiD· 1 shared Piya Temviriyanukul· 1 shared Sandrine van Hees-Stuivenberg· 1 shared

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Anastasia Tsaalbi-Shtylik

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Recent·Most cited

Molecular BiologybioRxivPreprintDec 18, 2025

Clastogenesis by nucleotide lesions requires the completion of two cell cycles.

Jacob G. Jansen, Piya Temviriyanukul, Daniel C. de Groot…·Niels de Wind

The paper identifies a delayed mechanism of clastogenesis where unrepaired nucleotide lesions in single-stranded DNA persist through mitosis and generate clastogenic DSBs during the subsequent S phase.

DOI 10.64898/2025.12.16.694654

experimental assay

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