Author

Jacob M. Young

University of Louisville

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:human· 1

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Archana JalligampalaiD· 1 shared Bhubanananda Sahu· 1 shared Caitlin A. Turner· 1 shared Caitlin Mooreman· 1 shared David C. Alston· 1 shared Derek Jantz· 1 shared Francesca BaroneiD· 1 shared Gita Jaikumar· 1 shared

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Archana JalligampalaORCID

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Recent·Most cited

NeurosciencebioRxivPreprintSep 25, 2025

RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones

Archana Jalligampala, Jacob M. Young, Jack Feist…·Maureen A. McCall

This study demonstrates that RHO1-2 meganuclease gene editing can arrest rod degeneration and restore retinal function in a pig model of P23H rhodopsin-induced retinitis pigmentosa.

1 citation

humanexperimental assay

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