TMEM106B mediates ACE2-independent replication of the SARS-CoV-2 S-E484D variant in airway-derived cell models
Ming Xia, Qibo Wang, Maritza Puray-Chávez, Kyle M. LaPak, Zhuoming Liu, Sathvik Palakurty, Paul W. Rothlauf, Sean Hui, Natalie Stegman, Marjorie Cornejo Pontelli, Jacob Marsh, Anayat Bhat, Celeste M M. Karch, Daved H. Fremont, Ramón Lorenzo-Redondo, , Sebla B. Kutluay
This study identifies TMEM106B as an alternative receptor for SARS-CoV-2 S-E484D variant entry, independent of ACE2, in airway-derived cell models.
bioRxiv · Oct 30, 2026 · PreprintMicrobiology