NeuroscienceMolecular NeurodegenerationPeer-reviewed
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein…·J. C. Rochet
The paper compares neurotoxicity of human A53T and mouse α-synuclein variants, finding mouse aSyn is less toxic due to C-terminal substitutions reducing membrane-induced aggregation and vesicle permeabilization.