Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain
Elvis Amurrio, Janvi Patel, Marie Danaher…·Michy P. Kelly
This study identifies molecular mechanisms regulating PDE11A4 liquid-liquid phase separation and shows that PDE11A inhibitors can reverse it in cells and brain.