Author
Radboud University Medical Center
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Eline van Hugte, Elly Lewerissa, Ka Man Wu…·Nael Nadif Kasri
This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.
Britt Mossink, Jon-Ruben van Rhijn, Shan Wang…·Nael Nadif Kasri
This study investigates the role of CDH13 in regulating GABAergic inhibition in human-derived neuronal networks and shows its impact on E/I balance.
Teun M. Klein Gunnewiek, Eline van Hugte, Monica Frega…·Tamás Kozicz
This study shows that mitochondrial dysfunction in human neurons, caused by high heteroplasmy of the m.3243A>G variant, leads to impaired neural development, reduced synaptic connectivity, and decreased network activity.
Monica Frega, Martijn M. Selten, Britt Mossink…·Nael Nadif Kasri
The paper investigates how mutations in distinct genes causing intellectual disability and autism affect neuronal network development, finding shared effects on excitability and synaptic function.
Monica Frega, Katrin Linda, Jason M. Keller…·Nael Nadif Kasri
This study shows that EHMT1 deficiency in human neurons leads to NMDAR hyperfunction, causing neuronal network dysfunction in Kleefstra syndrome, and demonstrates pharmacological rescue of these phenotypes.