Jason Rosch

Mucin promotes pneumococcal colonization via autolysis suppression and tryptophan-mediated immune modulation

This study shows that mucin promotes pneumococcal colonization by suppressing autolysis and modulating immune responses through tryptophan biosynthesis.

The global evolutionary dynamics of natural capsule switching in a human-restricted bacterial pathogen

This study examines capsule switching in Streptococcus pneumoniae using whole-genome sequences, finding that switching is limited to specific capsule-type pairs and influenced by genetic and ecological factors.

RNA Quality Control Enables Antibiotic Tolerance

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining Streptococcus pneumoniae Invasion of Respiratory Epithelial Barriers

Antibiotic Persistence Emerges from Cell-State-Driven Transcriptional Reprogramming

The paper shows how transcriptional heterogeneity and redundancy in stress responses shape antibiotic persistence in Klebsiella pneumoniae using single-cell RNA sequencing and functional assays.

Resistance, heteroresistance and fitness costs drive colistin treatment failure during Acinetobacter baumannii murine pneumonia

Mechanisms of 10-Hydroxyoctadecanoic acid resistance in Streptococcus pneumoniae

This study identifies h18:0 as a toxic fatty acid produced by S. aureus that targets S. pneumoniae, and reveals genetic mechanisms allowing pneumococcus to resist its toxicity.