Ralph R. Isberg

This study investigates how Yersinia pseudotuberculosis responds to macrophage-released metabolites during growth in synthetic microcolonies, identifying nitrosative stress and itaconate as key factors.

This study shows CD59 supports Yersinia pseudotuberculosis T3SS function by maintaining plasma membrane dynamics and lipid microdomain organization.

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

The paper identifies essential genes in Acinetobacter baumannii that support efflux pump overproducer fitness during ciprofloxacin treatment, revealing roles in outer membrane integrity and pH homeostasis.

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

The paper shows that Invasin-coated plates enable long-term 2D expansion of epithelial organoids from multiple species, offering an alternative to Matrigel/BME.

The paper identifies LegA7 as a cysteine protease in L. pneumophila that regulates MAPK pathway activation through conserved residues and ankyrin repeats.

The paper presents a yeast-based method to identify informative missense mutations in bacterial effector proteins and validates it using three effectors from Legionella pneumophila.

This paper introduces transcriptomic entropy as a generalizable predictor of bacterial fitness and antibiotic sensitivity across species and stress conditions using RNA-Seq and experimental evolution data.

This paper identifies mutations that alter fluoroquinolone sensitivity in Acinetobacter baumannii and shows that preferential Topo IV poisoning leads to prophage induction and SOS response activation.