Juan Cesar Federico Ortiz-Marquez

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

This study investigates the role of Dma2 in OMV biogenesis and colonization fitness in Bacteroides thetaiotaomicron, showing that dma2 mutation increases OMV production and affects polysaccharide utilization loci expression, leading to reduced colonization fitness.

The paper identifies proteins essential for maintaining fitness in Acinetobacter baumannii strains overexpressing RND efflux pumps, highlighting the role of outer membrane integrity and compensatory mechanisms.

This study identifies a novel family of Dual Membrane-spanning Anti-sigma factors (Dma) that regulate Outer Membrane Vesicle (OMV) biogenesis in Bacteroides thetaiotaomicron.

This paper introduces transcriptomic entropy as a generalizable predictor of bacterial fitness and antibiotic sensitivity across species and stress conditions using RNA-Seq and experimental evolution data.