Jeanette H. W. Leusen

The paper identifies inhibitory Nectin-2/TIGIT interactions between CD163+ macrophages and CD8+ T cells in neuroblastoma tumor niches, linking them to poor patient outcomes.

This paper develops a retargeted adenovirus system to produce IgA antibodies and CD47 blockers in tumors, enhancing innate immune responses and reducing tumor volume in mice.

This study shows that targeting C2 reduces complement activation in human kidney ischemia-reperfusion injury models using 2D and 3D in vitro systems.

This paper characterizes the immune landscape of hepatoblastoma, revealing a myeloid-dominated environment with limited T cells and opportunities for macrophage-targeted immunotherapy.

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.