A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans
Thomas Sonntag, Shizue Omi, Antonina E. Andreeva…·Nathalie Pujol
The paper identifies spia-1 as a gene involved in immune activation in C. elegans by sensing cuticle damage through its secreted protein with a novel cysteine-cradle domain.