BioengineeringbioRxivPreprint
An engineered disulfide staple restricts lid loop dynamics and alters substrate specificity of phenylalanine ammonia-lyase
Rebecca Condruti, Likith Muthuraj, Jeevan K. Prakash…·Nikhil U. Nair
The paper investigates the role of a dynamic loop in AvPAL by engineering disulfide bonds to restrict its mobility, revealing its regulatory function in substrate specificity.
DOI 10.64898/2026.05.01.722275