BiochemistryJournal of Biological ChemistryPeer-reviewed
Mismatch type impacts interference and priming activities in the type I-E CRISPR-Cas system
Phong Tuan Phan, Meriç Öztürk, Elizabeth M. Dougherty…·Dipali G. Sashital
This study investigates how crRNA seed sequence mismatches affect interference and priming in the type I-E CRISPR-Cas system, finding that specific mismatches cause significant defects in immune function.
DOI 10.1016/j.jbc.2026.111401