Synthetic BiologybioRxivPreprint
Engineering antigen-driven co-stimulation and T helper cell activity into TCR-T cells with CD8-41BB fusion receptors enhances anti-tumor activity
Ivy Dutta, Justin Oh, Liz Cam…·Aaron Prodeus
This paper enhances TCR-T cell anti-tumor activity by engineering CD8-41BB fusion receptors, improving CD4+ and CD8+ T cell functions and tumor regression in mouse models.
DOI 10.64898/2026.07.27.739613