PhysiologyJournal of Molecular and Cellular Cardiology PlusPeer-reviewed
Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy
Inez Duursma, Linda Renata Micali, Edgar E. Nollet…·Diederik W.D. Kuster
This study shows that microtubule detyrosination in HCM causes nuclear shape changes and YAP1 signaling, which can be reversed by inhibiting detyrosination.