Author

Jewel Dyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Mathieu Maclos· 1 shared

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

Systems BiologybioRxivPreprintSep 18, 2026

Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification

Mathieu Maclos, Jewel Dyer

The paper develops a computational systems biology framework to model metabolic-epigenetic coupling in cellular senescence, showing how mitochondrial remodeling and alpha-ketoglutarate depletion inhibit KDM4/KDM6 and amplify SASP.

DOI 10.64898/2026.09.16.752165

humanbulk RNA-seq

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