Jia Chen

GC801-enabled AAV gene therapy in a neonate with Pompe disease

This paper describes the use of GC801 to reduce anti-AAV9 antibodies in a neonate with Pompe disease, enabling successful AAV9 gene therapy.

Whole-Proteome Screening and Multi-Modal Profiling of Antigen-Specific CD4+ T Cells at Single-Cell Resolution

The paper develops a high-throughput platform to profile antigen-specific CD4+ T cells at single-cell resolution, identifying immunogenic features and functional heterogeneity in viral and cancer contexts.

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

This paper identifies a novel penetration ring formed by secreted proteins in the rice blast fungus after cell wall penetration, which persists at the plasma membrane interface during invasion.

Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation

The paper reports cryo-EM structures of DHHC9-GCP16 and Erf2-Erf4 complexes, revealing that GCP16 stabilizes DHHC9 and that phospholipid binding and specific palmitoylation are essential for catalytic activity.

MicroRNAs Regulate the Wnt/Ca2+ Signaling Pathway to Promote the Secretion of Insulin in Pancreatic Nestin-Positive Progenitor Cells

The paper investigates how miRNAs regulate insulin secretion in pancreatic beta cells by controlling intracellular Ca2+ through the Wnt/Ca2+ signaling pathway.