Author

Jiahui Liu

City Of Hope National Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:software / tool· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Kun HuangiD· 2 shared Adolfo Garcı́a-OcañaiD· 1 shared Alon Roy L. Agua· 1 shared Bryce David Colon· 1 shared Changlin WaniD· 1 shared Chao QiiD· 1 shared Chatrawee DuangjaniD· 1 shared Chongli YuaniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBioinformatics

Kun HuangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of CYP8B1-specific inhibitors for metabolic diseases

Zhipeng Fang, Alon Roy L. Agua, Jennifer Jossart, Nisha Sharma, Xintian Lyu, Zhe Wang, Shili Zhang, Ji Sun, Linsen Shi, Juan Ayard, Maggie Chang, Jiahui Liu, Kevin Kou, John Shively, Adolfo Garcı́a-Ocaña, , Wendong Huang

This study develops CYP8B1-specific inhibitors that alter bile acid composition, remodel gut microbiota, and improve metabolic disease in a mouse model.

bioRxiv · Oct 22, 2026 · PreprintPharmacology & Toxicology

ARSA: an autonomous research scientist for target nomination in Alzheimer's disease and related dementias

Xueyang Li, Jiahui Liu, Jiannan Liu, Timothy I. Richardson, Jeffrey L. Dage, Rebecca C. Klein, Danny Z Chen, Kun Huang, Jie Zhang, Travis S. Johnson, Yiyu Shi

ARSA generates evidence-based target shortlists for Alzheimer's disease and related dementias by integrating natural language research interests with molecular data and cross-cohort evidence.

bioRxiv · Sep 24, 2026 · PreprintBioinformatics

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer's tau pathology and uncover human-specific neuronal vulnerability

Yanru Ji, Purba Mandal, Jiahui Liu, Wen Hu, Bryce David Colon, Changlin Wan, Raymond W. Pan, Dongkai Guo, Lijia Zhang, Xingjian Gu, Yang Yang, Kun Huang, Riyi Shi, Chao Qi, Chongli Yuan, , Ranjie Xu

This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.

bioRxiv · Jul 9, 2026 · PreprintNeuroscience

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus

Jiahui Liu, Chatrawee Duangjan, Ronald W. Irwin, Sean P. Curran

This study shows that loss of WDR23 in mice leads to increased NRF2 stability and antioxidant defense, affecting age-related hippocampal behaviors in sex-dependent ways.

Mechanisms of Ageing and Development · Apr 1, 2024Peer-reviewedMolecular Biology