Zhe Wang

Development of CYP8B1-specific inhibitors for metabolic diseases

This study develops CYP8B1-specific inhibitors that alter bile acid composition, remodel gut microbiota, and improve metabolic disease in a mouse model.

Disrupted chromatin architecture blocks B lymphopoiesis in Down syndrome

The paper develops ChromE-seq to study 3D chromatin architecture in fetal hematopoiesis, finding that T21 disrupts B-lineage development by altering chromatin connectivity and regulatory circuits.

Mechanophenotype of synovial fibroblasts correlates with patients' pathotypes and treatment response in Rheumatoid Arthritis

The paper identifies 'soft' and 'stiff' fibroblast states in rheumatoid arthritis using mechanophenotyping and transcriptomics, linking them to patient pathotypes and treatment response.

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

Geometric-aware and interpretable deep learning for single-cell batch correction via explicit disentanglement and optimal transport

iDLC corrects single-cell batch effects by explicitly disentangling biological and technical features and aligning distributions with geometric constraints, outperforming existing methods in preserving biological structure.

Early microglial priming in Alzheimer's disease revealed by ME-seq

The paper introduces ME-seq, a technology that profiles DNA methylation, gene expression, and chromatin accessibility in single nuclei, revealing early microglial priming in Alzheimer's disease.

Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism

This study develops bioengineered human skeletal muscle tissues that mature metabolically and functionally, capturing key aspects of glucose metabolism and response to exercise and pharmacological agents.

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participants

This study analyzes clonal hematopoiesis in over a million diverse individuals, identifying 72 genome-wide significant loci and linking CHIP to various phenotypes.