Quantitative occupancy of myriad transcription factors from one DNase experiment enables efficient comparisons across conditions
Kaixuan Luo, Jianling Zhong, Alexias Safi…·Alexander J. Hartemink
The paper introduces TOP, a Bayesian framework that quantifies TF occupancy across many conditions using a single DNase-seq experiment, showing changes in 1500 TF motifs across cell types, hormone exposure, and genetic backgrounds.