BioinformaticsbioRxivPreprint
Phenotypic Bioactivity Prediction as Open-set Biological Assay Querying
Yuze Sun, Xiaoman Zhang, Qiaoyu Zheng…·Weidi Xie
This paper introduces OpenPheno, a multimodal model that predicts bioactivity using phenotypic profiles and natural language descriptions, achieving strong zero-shot performance on unseen assays.
DOI 10.64898/2026.02.28.708711