ImmunologybioRxivPreprint
Modular counterplays shape condensation and signaling of chimeric antigen receptor
Yiran Jiang, Zhengxu Ren, Jijun Luo…·Jizhong Lou
This study shows that PD-1 disrupts CAR-LCK condensates by binding CAR, and adding a CD3ε module stabilizes these condensates, enhancing CAR T cell activity against solid tumors.
DOI 10.64898/2026.07.27.741008