Author

Jillian M. Silva

University of California, San Francisco

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Systems Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

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Carolyn Teragawa· 1 shared Frank P. McCormickiD· 1 shared John G. AlbeckiD· 1 shared Michael PargettiD· 1 shared Taryn E. GilliesiD· 1 shared

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2020-2020 · peak 1/yr

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Carolyn Teragawa

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Recent·Most cited

Systems BiologyMolecular Systems BiologyPeer-reviewedOct 1, 2020

Oncogenic mutant RAS activity is rescaled by the ERK/MAPK pathway

Taryn E. Gillies, Michael Pargett, Jillian M. Silva…·John G. Albeck

The paper quantifies ERK activity in RAS-mutant cells and finds that mutant KRAS isoforms produce similar ERK output ranges despite differing biochemical activity, due to pathway-level rescaling mechanisms.

58 citations

humanproteomics

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