Jin Zhang

Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis

This study shows that obesity increases atherosclerosis through an inter-tissue miR-30e-SLC7A11 axis, where adipose-derived miR-30e-5p targets SLC7A11 in vascular endothelial cells, leading to metabolic and functional impairments.

An integrated single-cell atlas of human lung across the lifespan

The paper constructs a single-cell atlas of the human lung across the lifespan, identifying new cell types and regenerative mechanisms linked to lung diseases.

Defining the RNA Modification Landscape of Multiple Myeloma Reveals METTL3-Dependent m6A Regulation of NEAT1

The paper defines the RNA modification landscape in multiple myeloma, identifying m6A modifications on lncRNAs and showing METTL3-dependent regulation of NEAT1 affecting MM cell survival.

ACE2 Phosphorylation Modulates Angiogenesis via the Activator Protein-1

This study shows that ACE2 phosphorylation at Ser-680 modulates angiogenesis by affecting AP-1 activation in vascular endothelial cells.

GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in mice

This study shows that GPR158 in pyramidal neurons affects social novelty behavior in mice by modulating synaptic transmission and glutamate vesicle density in the medial prefrontal cortex.

Deciphering Hierarchical Chromatin Domains and Preference of Genomic Position Forming boundaries in Single Mouse Embryonic Stem Cells

The paper develops HiCS, a method to identify hierarchical chromatin domains in single-cell Hi-C maps, revealing multiple factors and retrotransposons involved in boundary formation in mouse embryonic stem cells.

PhyloSuite: an integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies

PhyloSuite is a desktop platform that streamlines molecular sequence data management and evolutionary phylogenetics analysis by integrating tools and providing a user-friendly workflow.

A critical role of the T3SS effector EseJ in intracellular trafficking and replication of Edwardsiella piscicida in non-phagocytic cells

This study identifies EseJ, a T3SS effector, as critical for E. piscicida's intracellular survival and replication in non-phagocytic cells by preventing endosome-lysosome fusion and creating an ER-associated replication niche.

Overlooked polyploidies in lycophytes generalize their roles during the evolution of vascular plants

The paper reanalyzes the genome of Selaginella moellendroffii and finds multiple polyploidies, suggesting they played a key role in the evolution of vascular plants.

A fast multi-locus random-SNP-effect EMMA for genome-wide association studies

The paper introduces FASTmrEMMA, a fast multi-locus GWAS method that improves power, model fit, and speed compared to existing approaches.