Systems BiologybioRxiv
Protein homeostasis imposes a barrier on functional integration of horizontally transferred genes in bacteria
Shimon Bershtein, Adrian Serohijos, Sanchari Bhattacharyya…·Eugene Shakhnovich
This study shows that protein homeostasis limits the functional integration of horizontally transferred genes in bacteria by reducing the abundance of foreign proteins, and that this barrier can be overcome through evolutionary adaptation.
DOI 10.1371/journal.pgen.1005612