NeurosciencebioRxivPreprint
Intranuclear polyglycine aggregation drives neurodegeneration through epigenetic repression of chromatin accessibility and transcription
Yangye Lian, Shaoping Zhong, Jiaxin Huang…·Jing Ding
This study shows intranuclear polyG aggregates cause more severe neurodegeneration than cytoplasmic ones by repressing chromatin accessibility and transcription through epigenetic mechanisms.