Cancer BiologybioRxivPreprint
Testing the plasticity-first theory of tumor evolution with spatiotemporal lineage tracing
Jinhua Yang, Liangzhen Hou, Xue Wang…·Herrero-Herrero Ji
This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.