BiochemistrybioRxiv
Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures
Jinjian Hu, Wencheng Xia, Shuyi Zeng…·Yan-Mei Li
This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.
DOI 10.1038/s41467-024-46898-1