Author

Joan Onwunma

University of Toledo

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

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Banumathi SankaraniD· 1 shared Deepika GauriD· 1 shared Matthew L. WohleveriD· 1 shared S. P. AlleniD· 1 shared Sachini ThanthirigeiD· 1 shared Saeed A. BinsabaaniD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Banumathi SankaranORCID

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1 paper

Recent·Most cited

BiochemistryThe EMBO JournalPeer-reviewedMar 20, 2026

ALS mutations disrupt self-association between the Ubiquilin Sti1 hydrophobic groove and internal placeholder sequences

Joan Onwunma, Saeed A. Binsabaan, S. P. Allen…·Matthew L. Wohlever

This study presents the first crystal structure of the Ubiquilin Sti1 domain bound to a transmembrane domain, showing that ALS mutations disrupt their interaction and reveal internal placeholder sequences that regulate phase separation.

9 citationstop 1%

structural biologyexperimental assay

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