NeuroscienceeLifePeer-reviewed
Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome
Laura A. Lavery, Kerstin Ure, Ying‐Wooi Wan…·Huda Yahya Zoghbi
This study shows that loss of Dnmt3a or MeCP2 in inhibitory neurons leads to distinct but overlapping neurological and molecular effects, with mCH playing a key role in Rett Syndrome pathogenesis.
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