BiochemistryACS Chemical BiologyPeer-reviewed
Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R. Schneider…·Andreas C. Joerger
This study develops potent dual BET/HDAC inhibitors through pharmacophore merging and structure-guided optimization, showing improved potency and efficacy in cancer cell models.