Author
University of Oxford
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Nicholas T. Crump, Erica Ballabio, Laura Godfrey…·Thomas A. Milne
The paper shows BET inhibition reduces transcription but not enhancer-promoter contacts, suggesting these processes are separable.
A. Marieke Oudelaar, Robert A. Beagrie, Matthew E. Gosden…·Jim R. Hughes
The paper studies chromatin architecture changes during mouse erythroid differentiation using Tiled-C and shows enhancer-promoter interactions form during differentiation, not before gene expression.
Damien J. Downes, Matthew E. Gosden, Jelena M. Telenius…·Jim R. Hughes
The paper introduces a new method, NuTi Capture-C, that improves high-resolution chromosome conformation capture by reducing noise and increasing sequencing content, enabling reproducible genome-wide interaction profiles.
Jelena M. Telenius, Damien J. Downes, Martin J. Sergeant…·Jim R. Hughes
CaptureCompendium provides software tools to simplify the design, analysis, and visualization of 3C experiments, addressing the need for specialized bioinformatics skills in genome folding studies.
Damien J. Downes, Ron Schweßinger, Stephanie Hill…·Jim R. Hughes
The paper develops a platform combining ATAC-seq, DNaseI footprints, NG Capture-C, and machine learning to identify causal variants and genes for polygenic human traits.