BioengineeringbioRxivPreprint
Engineering a pH-sensitive humanized infliximab with improved potency and developability using STEM™
Paul D. Entzminger, Kevin C. Entzminger, Jonathan K. Fleming…·Toshiaki Maruyama
This study humanizes and engineers infliximab to improve its potency and developability, identifying LW2Y as a lead candidate with enhanced pH-dependent properties.
DOI 10.64898/2026.08.18.745573