Annie Jen

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

The paper quantifies enzyme burdens in glycolytic pathways of three bacteria, finding that thermodynamically favorable pathways require less enzymatic protein to sustain the same flux.

This study shows that adjusting pH and using SAA pretreatment improves biofuel production from drought-switchgrass hydrolysates.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.

The paper investigates how PKA signaling coordinates growth and metabolism in yeast during anaerobic xylose fermentation by analyzing transcriptomic, lipidomic, and phosphoproteomic data.