Andrea Galmozzi

This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.

The paper presents a comprehensive atlas of lysine acetylation in the mouse, identifying 17,952 sites across 15 tissues and highlighting shared and tissue-specific acetylation events.

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

The paper identifies a common fibro-adipogenic progenitor population in both white and brown adipose tissue using single-cell RNA sequencing and validates its physiological relevance through comparison with in vivo data.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

This study examines how different doses of HDAC inhibitors TSA and SAHA affect glial inflammatory responses to LPS, showing dose-dependent pro- and anti-inflammatory effects.