NeurosciencebioRxivPreprint
Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration
Xuehan Sun, Lidan Wu, Timothy C. Orr…·Miranda E. Orr
The paper uses single-cell spatial transcriptomics to analyze tau pathology in mouse brains, revealing cell-autonomous and non-autonomous effects of tau accumulation on gene expression and pathways.
DOI 10.1101/2025.11.19.689127