Joseph Gans

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

The paper inhibits Elovl1 in a mouse model of ALD to reduce VLCFA accumulation, finding it corrects lipid pathways but also causes unexpected transcriptional changes.

GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insults

This study investigates GPR17's role in oligodendrocyte precursor cell maturation and myelin regeneration, finding limited impact on myelin repair after injury.

Glial state changes and neuroinflammatory RIPK1 signaling are a key feature of ALS pathogenesis

This study identifies glial state changes and RIPK1 signaling as key features of ALS pathogenesis, showing that blocking RIPK1 delays disease onset and modulates glial responses.

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

Localized calcium accumulations prime synapses for phagocyte removal in cortical neuroinflammation

The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.