Glial state changes and neuroinflammatory RIPK1 signaling are a key feature of ALS pathogenesis
Matija Zelic, Anna S. Blazier, Fabrizio Pontarelli, Michael J. LaMorte, Jeremy Y. Huang, Ozge E. Tasdemir-Yilmaz, Yi Ren, Sean K. Ryan, Pavithra Krishnaswami, Mikhail N. Levit, Disha Sood, Yao Chen, Joseph Gans, Xinyan Tang, Jennifer Hsiao‐Nakamoto, , Timothy R. Hammond
This study identifies glial state changes and RIPK1 signaling as key features of ALS pathogenesis, showing that blocking RIPK1 delays disease onset and modulates glial responses.
bioRxiv · Apr 12, 2024 · PreprintNeuroscience