Author

Joshua B. Black

Duke University

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Biology Disciplines

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Genomics· 1

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

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Alejandro BarreraiD· 1 shared Celine E. de Esch· 1 shared Charles A. GersbachiD· 1 shared Dahlia Rohm· 1 shared Daniel J. Morone· 1 shared Derek J.C. TaiiD· 1 shared Michael E. TalkowskiiD· 1 shared Nahid IglesiasiD· 1 shared

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Alejandro BarreraORCID

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1 paper

Recent·Most cited

GenomicsCell GenomicsPeer-reviewedFeb 1, 2025

Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing

Dahlia Rohm, Joshua B. Black, Sean R. McCutcheon…·Charles A. Gersbach

The paper uses CRISPR-based epigenome editing to activate the silenced maternal SNRPN gene in PWS iPSCs, showing that DNA demethylation can lead to stable expression.

27 citationstop 1%

humanDNA methylation

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