Author

Joshua Gerninghaus

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 1

Frequent Co-Authors

Andreas KrämeriD· 3 shared Lewis ElsoniD· 3 shared Stefan KnappiD· 3 shared Susanne MülleriD· 3 shared Thomas HankeiD· 3 shared Benedict‐Tilman BergeriD· 2 shared Christopher LenziD· 2 shared Francesco A. GrecoiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Andreas KrämerORCID

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3 papers

Recent·Most cited

BiochemistryACS Medicinal Chemistry LettersPeer-reviewedOct 14, 2025

Un-LOK-ing a new approach for conformational selective targeting of STK10 (LOK)

Martina Dettenhöfer, Laura Nadine Tandara, Jennifer Alisa Amrhein…·Thomas Hanke

The paper describes the optimization of a macrocyclic scaffold to develop a selective STK10 inhibitor with nanomolar activity and good kinome selectivity.

3 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryJournal of Medicinal ChemistryPeer-reviewedJul 19, 2024

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer…·Thomas Hanke

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

13 citations

humanexperimental assay

𝕏 PostBluesky

BiochemistryEuropean Journal of Medicinal ChemistryPeer-reviewedJul 14, 2024

Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting

Francesco A. Greco, Andreas Krämer, Laurenz Wahl…·Stefan Knapp

The paper designs and evaluates chemical linchpins targeting CK2α with a novel binding mode combining allosteric and ATP competitive elements, showing high selectivity and low micromolar activity.

6 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky