BiochemistryJournal of the American Chemical SocietyPeer-reviewed
Macrocyclic Peptides Containing an Imidazopyridinium (IP+) Unit Display Enhanced Passive Cell Permeability
Bo Li, Joshua Parker, Skyler A. Briggs…·Thomas J. Kodadek
This study shows that adding an imidazopyridinium (IP+) unit to macrocyclic peptides enhances their passive membrane permeability, enabling them to enter cells and inhibit intracellular targets like p53-MDM2.
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