BiochemistryJACS AuPeer-reviewed
Paralogue-selective degradation of the lysine acetyltransferase EP300
Xuemin Chen, McKenna C. Crawford, Ying Xiong…·Jordan L. Meier
This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.
12 citations