Jordan L. Meier

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

This paper evaluates the potency and selectivity of MYST KAT inhibitors using chemoproteomic profiling and identifies new complex members, highlighting dose-dependent inhibition patterns and potential therapeutic applications.

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.

This study characterizes TkNat10, an RNA acetyltransferase from T. kodakarensis, showing its role in thermotolerance and its ability to modify RNA substrates with specific sequence preferences.

This study investigates the effects of ribosome biogenesis inhibition in vivo by deleting Nat10 in mice, revealing p53-dependent and -independent consequences on acinar cell function and tumorigenesis.

This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.

The paper investigates the role of SNORD13 in rRNA acetylation across eukaryotes, showing its requirement in human and zebrafish but not in yeast or C. elegans.