GeneticsbioRxivPreprint
Winners curse correction and variable thresholding improve performance of polygenic risk modeling based on summary-level data from genome-wide association studies
Jianxin Shi, Ju-Hyun Park, Jubao Duan…·Nilanjan Chatterjee
This paper improves polygenic risk scores by applying winners curse correction and variable thresholds to GWAS summary data, enhancing prediction accuracy for some diseases.
DOI 10.1101/034082