BiochemistrybioRxiv
Targeted Degradation of METTL3 Against Acute Myeloid Leukemia and Gastric Cancer.
Kyubin Hwang, Juhyeon Bae, Yoo-Lim Jhe…·Taebo Sim
This study develops KH12, a METTL3 degrader, showing potent anti-leukemia and anti-gastric cancer effects through m6A-dependent and -independent mechanisms.
DOI 10.1016/j.ejmech.2024.116843