Molecular BiologybioRxiv
Direct binding to RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage
Julyana Acevedo, Shan Yan, Matt Michael
This study identifies a direct interaction between TopBP1 and RPA-coated ssDNA, showing how TopBP1 is recruited to DNA damage sites to activate ATR.
DOI 10.1074/jbc.m116.729194