α-synuclein aggregates induce c-Abl activation and neurodegeneration by a redox stress mechanism
Soumitra Ghosh, Seok Joon Won, Rebecca Fong, Nicholas J. M. Butler, Arianna S Moss, Candance Wong, June Pan, Jennifer Sanchez, Long Wu, Jiejie Wang, Fredric P. Manfredsson, Raymond A. Swanson
This study shows that α-synuclein aggregates cause c-Abl activation via redox stress, leading to neurodegeneration, and that N-acetyl cysteine can block this process in Parkinson's disease models.
bioRxiv · Nov 13, 2019 · PreprintNeuroscience