Seok Joon Won

Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered afterstroke

This study evaluates hexokinase-2 inhibitors' effects on post-stroke inflammation and neuroprotection, finding that selective inhibitors reduce microglial activation and improve functional outcomes.

Stress hyperglycemia exacerbates inflammatory brain injury after stroke

This study shows that post-stroke hyperglycemia worsens brain injury by increasing oxidative stress and impairing motor recovery in mice.

Superoxide enters neurons via LRRC8A-containing volume-regulated anion channels

This study shows superoxide enters neurons directly through LRRC8A-containing volume-regulated anion channels, blocking oxidative stress and glutamate excitotoxicity.

Recovery of consolidation after sleep following experimental stroke - interaction of slow waves, spindles and GABA

This study shows that sleep-dependent memory processing is altered after stroke in rats, with impaired spindle coupling to slow oscillations, and that reducing GABA can restore physiological sleep states and improve recovery.

α-synuclein aggregates induce c-Abl activation and neurodegeneration by a redox stress mechanism

This study shows that α-synuclein aggregates cause c-Abl activation via redox stress, leading to neurodegeneration, and that N-acetyl cysteine can block this process in Parkinson's disease models.

Cofilin-actin rod formation in neuronal processes after brain ischemia

This study examines cofilin-actin rod formation in different mouse models of brain ischemia and finds that rod formation varies with ischemic conditions and reperfusion timing.