Molecular BiologybioRxivPreprint
G2-to-G0 cell cycle exit underlies sensitivity to ATR inhibition via the p53-p21-RB1 axis
Celina Sanchez, Carlos A. Origel Marmolejo, Juyoung Lee, Joshua C. Saldivar
The paper identifies the p53-p21-RB1 axis as a determinant of breast cancer sensitivity to ATR inhibition, showing it drives G2-to-G0 cell cycle exit and is modulated by MDM2.
DOI 10.64898/2026.04.28.721427